Early Marjolin’s Ulcer after Minimal Superficial Burn

Dear Editor, Marjolin’s ulcer is a rare, well-defined, uncommon, and often aggressive malignant transformation,1 secondary to burn injuries and other inflammatory changes such as venous insufficiency ulcers, pressure ulcers, traumatic wounds, cystostomy sites, scarring from lupus, amputation stumps, chronic lymphedema, chronic pilonidal sinuses, hidradenitis suppurativa, chronic ulcers of leprosy, necrobiosis lipoidica, and chronic osteomyelitic fistulae.2 The incidence of burn scars undergoing malignant transformation has been reported to be 0.77 to 2%.3 The incidence of Marjolin’s ulcer in lower extremities is more frequent than that in upper extremities. Marjolin’s ulcer occurs at any age and in all races, and men are more commonly affected than women (3:1).4 Over 90% of all Marjolin’s ulcers degenerate into malignancies of epidermoid organs such as squamous cell carcinoma, basal cell carcinoma, and malignant melanomas. Sarcomas can occur but they are uncommon.3 The usual histological finding is squamous cell carcinoma,5 and it is thought that basal cell carcinoma occurs when the burn is more superficial and the hair follicles and sebaceous glands are spared.1 Basal cell carcinoma is generally deemed a very aggressive tumor with higher rates of regional metastasis. The usual presentation of Marjolin’s ulcer is a non-healing ulcer arising after traumatized or chronically inflamed skin.5 The exact causes of this malignant transformation are unknown,4,6 with various etiological factors having been implicated such as 1 Genetic factors like mutation of the FASAPO-YCD, 2 Low T cell counts, 3 Lymphatic obliteration and poor lymphatic regeneration, 4 Toxins released from damaged tissues, 5 Decreased vascularity of the scar, and 6 Miscellaneous factors such as irritation, antibodies, DNA mutations, local toxins, and infection. Marjolin’s ulcer is classified into acute and chronic subgroups. Acute scar carcinoma, which is rarely seen, occurs sooner than one year after injury.7 Acute Marjolin’s ulcer is more often basal cell carcinoma and is associated with more superficial burn scars.5 The latency period is inversely proportional to the patient’s age at the time of burn injury.1 The mean average period of chronic carcinoma development, more frequent type, is 35.5 years.7 We herein present an otherwise healthy 54-year-old Jewish man, who developed Marjolin’s ulcer only 6 weeks after his burn injury. The patient had superficial scald burn injuries, about 3% of the body surface area, on his right foot and right hand, which healed with conservative management after 3 weeks. Two weeks later, a 10-mm exophytic fragile nodule, which bled with minor manipulation, was noted in the dorsal aspect of his right hand. The nodule was excised completely, the wound was closed primarily, and the tissue was sent for histopathologic evaluations. The histopathology of the lesion was well-differentiated squamous cell carcinoma (figures 1 and 2). Consequently, re-excision with a 10-mm margin was done, and full-thickness skin graft was